To detect the telomerase and vascular endothelial growth factor ( VEGF) activity in liver of mice with advance stage of schistosomiasis japonica and to discuss the relationship between periportal cirrhosis and hepatocarcinoma. 目的检测晚期血吸虫病肝组织的端粒酶和血管内皮细胞生长因子(VEGF)的活性,探讨日本血吸虫病肝硬化与恶性变的相关性。